I was recently reading an article about how birdsong influences the expression of small RNAs called... microRNA that in turn, influences gene expression.

It's absolutely fascinating. If you think about it, everything happens with gene-expression. Every little sound or image or any sensory input we receive from outside changes and temper the way our genes express in an ever-changing interaction.

I wonder what an intense episode of stress does to our immune-system related genes... Does it promote allergic reactions? Does it suppress the immune-system in a counter-productive move? I have this slight inkling of a doubt that this year, my escalating stress, nightmares about graduating and complete lack of restful sleep day in and day out is probably the primary cause of all my out-of-the-blue allergies.

I have never had allergies to ANYthing before. I usually cope with stress well... but then I have also had family around me in the past to buffer most extreme stressful times. I have sailed through most 40 hour shifts with nothing more than sore throats in the past. But I think if I had to do those shifts now, I would fall seriously sick. Things have changed so much.

So coming back to microRNAs, I wonder how microRNA influenced gene-expression charts the course of body physiology and especially, immune-system function. Sounds like an excellent future avenue ripe for investigation - especially since we can knock some of these microRNAs out with drugs...

Puts her spin on Charles Dickens

I saw no shadow ...
I saw nooo shadowwwwwwwwwwwww ...
I saw noooooooo shadooooowwwwwwwwwwwwwww ...
of another parting ...
from her.

Someday I want to find out if I can belt out a simple operatic tune. Maybe when all this messy academic phase is past and I am a decade older (and not dead or sick with cancer and chemotherapy-related side-effects) I want to take some voice training and see how long I can draw my breath out into a loooonnng note in tune.

Turns out that the ingredient list and the nutrient profile I posted for Aunt Jemima Blueberry waffles in my last journal were from some older versions of their waffles. They were the ones available online on the Aunt Jemima website. I should have proof-read them more carefully. I vaguely remember thinking that this was not what I saw on the box as I posted the waffle battle journal. But I put that thought on hold because I went back to some number-crunching and r-coding before I dropped into unconsciousness at my desk.

I was surprised when (e:Paul) pointed out the tertiary-Butylhydroquinone (TBHQ) in the list. Because I distinctly remember the box saying "no preservatives". So here are the real photos of the Aunt Jemima Blueberry Waffles box I bought yesterday.


Check: No preservatives.


And 10 calories less that what I posted. They really changed the recipé.

I dreamt about waffles for 3 days in a row till it got out of hand today morning. I could smell them while I was eating apples. I examined hormonal and physiological reasons behind the craving hoping to expose the irrationality of it all. I even considered my new anti-allergy buddy Claritin as one of the culprits behind the craving.

But in the end, I am sorry to say, the waffle craving totally won out. I trotted straight from work to Pricerite to get frozen waffles. I was then faced with CHOICES!



I thought Eggo was the only one who made waffles. But no. There were Aunt Jemima waffles battling for my attention as well. Regardless of the majority vote in this thread: I chose Aunt Jemima. The nutritional profiles were pretty similar.

Eggo Blueberry Waffles Nutrition data:

Aunt Jemima Blueberry Waffles Nutrition data:


The ingredient list was also rather similar

Aunt Jemima waffles ingredients:
INGREDIENTS: ENRICHED WHEAT FLOUR (FLOUR, NIACIN, REDUCED IRON, THIAMIN MONONITRATE, RIBOFLAVIN, FOLIC ACID), WATER, PARTIALLY HYDROGENATED SOYBEAN OIL, ARTIFICIALLY FLAVORED BLUEBERRY BITS (SUGAR, DEXTROSE, SOYBEAN OIL WITH TBHQ, SOY PROTEIN, SALT, CITRIC ACID, CELLULOSE GUM, ARTIFICIAL FLAVOR, MALIC ACID, RED 40 LAKE, BLUE 2 LAKE), SUGAR, WHEY. CONTAINS 2% OR LESS OF: LEAVENING (SODIUM ACID PYROPHOSPHATE, SODIUM BICARBONATE [SOY LECITHIN]), WHOLE EGGS, CALCIUM CARBONATE, CALCIUM CHLORIDE, SALT, CORN SYRUP SOLIDS, CORN STARCH, COLORED WITH (YELLOW 5, YELLOW 6), FORITIFIED WITH (REDUCED IRON, NIACINAMIDE, PYRIDOXINE HYDROCHLORIDE [VITAMIN B6], RIBOFLAVIN [VITAMIN B2] , THIAMINE MONONITRATE [VITAMIN B1], CYANOCOBALAMIN [VITAMIN B12]), NATURAL AND ARTIFICIAL FLAVOR (DEXTROSE, CORN STARCH, NATURAL AND ARTIFICIAL FLAVORS), SOY LECITHIN. CONTAINS: SOY, EGGS, MILK, WHEAT

But somehow, I chose Aunt Jemima because the phrase "Aunt Jemima" invoked a friendly image of some homely aunt making a fresh batch of waffles in the morning. Aunt Jemima won the battle on psychological grounds.

Now have a website!!! You know you want to click through:


They have most of their formerly mysterious wholesale catalogue online: I know for a fact it's not for restaurants alone. You can get fresh cases of salads and chocolate or whatever you like from them if you can consume that much. I have, in the past, eaten their mesclun salads with every meal for a whole month till I finished the case. :-)

And they carry the whole range of Ecce Panis Artisan breads: Now, if only they would take online orders and allow me to pay with credit, I don't have to trek all the way to Grant Street for my Guercio fix. :)

I have been learning a lot about stainless steel cookware these past few days. The best guide to pots and pans on the whole internet is arguably this page:

Apparently, when you are buying stainless steel pots and pans, it better to get tri-ply construction for the entire pan (bottom as well as walls) instead of an encapsulated bottom alone. Food is more likely to burn or cook non-uniformly where the encapsulation ends.

According to most cooking pan guides I read through, a complete copper tri-ply with stainless steel is the best type of cooking pan construction but is quite impractical for people on a budget. It is almost like buying a pan made fully out of one of the "precious" metals. The next best thing is aluminium tri-ply construction.

Riveted handles are better. So are pots and pans made of 18/10 (Chromium/Nickel) stainless steel.

Looks like satisfies pretty much all of those criteria... and doesn't break the budget.

You would like "Young Victoria" very much. :-)

I agree with all the praise heaped on that poster. And I love that royal purple. An awesome colour, in general.

I now think stretching is the key to being fit. Every element of ballet and yoga that make me feel awesome about myself involve stretching in some form. I think this post summarizes the value of stretching:

Also has this nifty basic stretches diagram:


What if you used every small timespan of just twiddling your thumbs to stretch a muscle instead? How many stretches could you accumulate in a day? How much fitness would you gain? What if you stretched whenever you remembered to throughout the week, throughout the month, pretty much whenever it was feasible? Would it make a difference to your body?

I am going to find out!! Mid-year resolution #1!

If (e:strip) is not about stalking people from my 3rd grade or shouting in clipped sentences, then what is it about for me? I just came to a conclusion that I don't use it enough or rather, I have set some artificial limits for what I want to write here. I was telling (e:Paul) that (e:strip) is like the Fedora of online technology. Why not make it the Fedora of my thoughts and life as well?

I think writing for an audience tempers all of my posts here. What if I didn't write for an audience and wrote exclusively for myself? I am going to try that experiment starting today. I want to be able to write whatever I am thinking about, whenever I am thinking about it here and include links and references in context to those thoughts along with my posts.

(e:Paul) already publishes most of his life on his journal. I think that is the true meaning of (e:strip) - to be able to come online and just document what is going on in your conscious and subconscious mind and not really worry about why you are driven to put it online. The alternate meaning of (e:strip) is to be able to electronically strip the clouds, the salt scales and the tartar away from your core thoughts and just put them here for reference and sometimes, increased clarity.

Of course, I will not put work-related writing here... That is reserved for my citation manager. :)

(e:Paul), (e:Terry) and I were discussing the relative merits of Claritin (Loratadine) in comparison with Benedryl (Diphenhydramine) in combating symptoms of allergy. Apart from remembering that Benedryl is a 1st generation antihistamine and that Loratadine is a 2nd generation antihistamine, I was sorry to note that I remembered nothing more about their pharmacology or specifics of how they differed from each other in their mechanism of action.

What follows is a dry account of the differences. Well... maybe not so dry because I am interested. :-)

Any allergic episode has two components: the early and late component. The early component is when the immunoglobulins (type E) recognize allergens, interact with the foot-soldier cells of the immune system. This interaction promotes the release of histamine, prostaglandins and leukotrienes from granules within not only mast cells, but also basophils, lymphocytes, and other reservoirs. Histamine then binds to receptors on nerves and blood vessels and leads to sneezing, tearing up, congestion and whatnots. Antihistamines compete with histamine for spots on the receptor and thus competitively reduce or completely block its action.

1st generation drugs such as diphenhydramine (Benedryl) also have additional anticholinergic, anti-serotonin, local anaesthetic, as well as sedative effects that might either provide a broader spectrum of relief from allergies or might just end up giving people more side effects (which explains the trippy experience I had.)

The late component of allergy is a plain inflammation reaction in the tissues mediated by immune cells called T-helper cells type-2 (Th2) and a host of cytokines (hormones/signalling molecules of the immune system). The inflammatory component feels exactly like a cold with the same reactions. In addition, the inflammatory component primes the immune response or "sensitizes" the immune system to even swifter allergy-induction in response to future allergens.

Loratadine (Claritin) not only binds to the histamine receptor, it also prevents the release of histamine as well as prostaglandins from mast cells - thus preventing "mast cell activation". Loratadine also has some effect on Th2 cells and suppresses some of the later inflammatory phase. It decreases the production of some of the late-phase cytokines. So it's not just an antihistamine. It also has none of the other wider receptor blocking effects of 1st gen antihistamines.

If you are inclined to read the nitty-gritties or how Loratadine acts on the immune system, here's a good review:
::READ PDF::