What's an absolutely spellbinding story without a montage!??
Ready?? Cue the music >>>

::DOWNLOAD SOUND::

I just received an awesome mail in my inbox!



(E:boxerboi) successfully completed the Musselman Triathlon Challenge in 1:38:29!



The Triathlon Challenge started early in the day...


It was no walk in the park!!


Or even a casual dance by the disco!


It was a genuine time-bound sweat-drenched exhausting amphibious race!!


A arduous triple trek through the tunnel of exertion and grit!


But (e:boxerboi) completed it with flying colours!!

(E:boxerboi)!!!!!!

YOU ARE MY HERO!

Or so I think.

Since I have a deadline, quite naturally, I have been afflicted by the ODES ((e:tinypliny,38711)) and I am off gallivanting to distant realms of the www. I chanced upon Chow Chocolat's myspace page. It lists the store as a 25 year old female in Buffalo, NY. I wonder if that is the demographic of clientele they hope to attract or just how young they feel... Anyway, their page has an intriguing little song called "Berlin" by a band called "Casperous Vine". It also has a to the band.

I couldn't help following it and the revelation of the evening is that its Johnny Depp's band! According to the page, Johnny Depp a.k.a Paul Christopher Kozlowski plays the Bayan, the Accordion, several types of Guitar (including Classical, Electric, Nylon), the oud, the fretless bass, vibraphone, jew harp, jaymar, porpoise, the trither, anu, marimba, glocks, vox, didj, scrap metal, keyboard/synthesizer, mandolin, percussion, flute, cello, violin and also an exotic and colourful looking self-assembled instrument called the Gilgamesh! Casperous Vine has released a CD compilation that is reviewed here. Their music is described as avante garde progressive electro-acoustic world-fusion! Kozlowski also plays in another rather interesting band called the Terrible Elephant. Give a listen to the song called "roompa" on this and you'll know what I mean.



Is there a limit to this man's seemingly endless and fascinating qualities?!

- Passionate Cook
- Founder of an innovative band (and probably plays in two more).
- Composer of exotic music
- Can build musical instruments from Scratch.
- Plays several musical instruments
- Works at Chow Chocolat
- Looks heartbreakingly like Johnny Depp!
- Has a very charming smile and is extremely down-to-earth.
- Shook hands with Hillary Clinton

While I was google-stalking this captivating personality, I found (e:Jim)'s Flickr stream! Yep. Just like that Bacon bloke is six degrees away from everyone on the planet, I am convinced that (e:Jim) is just a google-stalk away from everyone! (e:Jim) and (e:James) are virtual friends with another Flickr photo-enthusiast called Planet Tyler whose Summer '07 muse was none other than Johnny Depp Kozlowski!


Buffalo is an incredibly personal city. :)

_________
PS: Readers having trouble placing this post in context should refer to this post about Chow Chocolat: (e:tinypliny,44289)

I found a host of nifty and useful research tools out there that are totally worth sharing multiple times. These might be just the life-savers, organizers and new-idea germinators that graduate students and serious researchers are looking for. Can't guarantee that they would make your life easier though...

1. Keep tabs on what's happening in the peer-reviewed research world. From the website:
Discussing and Creating Peer-Reviewed Research: Research Blogging

Do you like to read about new developments in science and other fields? Are you tired of "science by press release"? Research Blogging is your place. Research Blogging allows readers to easily find blog posts about serious peer-reviewed research, instead of just news reports and press releases.

The RSS feed is here:

The real question is however, just how many RSS feeds can one read before it turns into an unmanageable information overload and just becomes toxic??

2. Making a Checklist and sticking to it: The Tada list

It has a very simple interface that I use to make a checklist of things I need to do everyday. Finishing the tasks on the list actually is very satisfying. I find that the more I use it, the more disciplined I want to be in my reading and work goals. I know I can very well make lists on paper. But if I use an online interface (a) I don't have to worry about losing my lists, (b) I can access and tick off my list from anywhere (Well, almost. Any place that has net access). (c) Save paper! (d) copy out the list if I need to be in a really remote location, or maybe a conference.

3. An excellent comparison of Reference Managers: This is an exhaustive wiki about all the reference managers out there. Some of them are free, web-based and help you access your references anywhere and anytime. The next time that dreaded hard-disk crash happens or worse, your laptop or USB drive gets stolen, you don't have to worry about your dissertation references anymore. I currently use RefWorks - that is free via my University and via Roswell. However, I am actively exploring other free and open-source alternatives such as:
-- Connotea from the Nature Publishing Group ->
-- Zotero - a Firefox Extension for Reference Management ->


4. Synchronizing Notes, PDF Annotations, Anywhere, Anytime: Note-Taking Software Comparison: If you print out PDFs just because you can't mark them up online/on-screen, there is help! By using some of these FREE note-taking software you can mark and highlight those PDFs on-screen, avoid all that paper clutter and save all those reams of paper (and trees). I currently use Jarnal - a platform-independent, open-source, free Java-based note-taking software ->

Options. Options. So many Options.

I just had a zen moment in the interpretation of Linkage Disequilibrium Maps. (Also called LD maps, LD blocks, LD triangles - take your pick.) Turns out I was actually sweating 1st grade stuff!

I found that NO ONE explains this EXTRAORDINARILY SIMPLE thing in their umpteen papers, reviews, tutorials and what-nots. I just want to post this here so that when people google this simple little question, they find an equally simple and straight-forward answer!

This is an example of what a very small section of a Linkage Disequilibrium Map or an LD Map looks like.


Concentrate on the upper part of the map.


The thick blue line represents a strand of a chromosome. The white bars on the blue line of the chromosome are SNPs (Single Nucleotide Polymorphisms) that have been identified and sequenced. This means that we know what initial Nucleotide base has morphed into what final Nucleotide base. (Thus making it a polymorphic locus - or a position on the chromosome that exists in more than one form. The two forms are the intial nucleotide base and the final nucleotide base.)

These SNP locations or loci are labeled in this picture as 1, 2, 3, ... and so on. Each of these SNPs has a name that starts with rsXXXXX where XXXXX is some numeric code. Each SNP is represented by a labeled grey triangle below the thick blue line (the chromosome).


The purpose of an LD map is to tell us whether any two given SNPs are INHERITED TOGETHER in an offspring. In other words, we want to know if any two given SNPs are in Linkage Disequilibrium.

An example: Are say, SNP #5 and SNP #9 in linkage disequilibrium? You trace down the column leading from grey triangle #5 or SNP#5 (Name: rs2299433) going toward SNP #9 (rs2237717). Do the same for SNP #9 going toward SNP #5.


The square in which the columns leading from SNP #5 and SNP #9 intersect is the one you should focus on. I have encircled it above. As you can see its a LIGHT RED and has a number, 75. Thus SNP#5 and SNP #9 have a correlation of 0.75 and are in fairly high linkage disequilibrium with each other.

In simple terms, if your square of focus is a deep red, then the two SNPs you are interested in have the highest correlation with each other and have a highest Linkage Disequilibrium. Thus, one of them can easily act as a proxy for another. The lighter the shade of red, the lesser is the correlation between the two SNPs. For example, SNP #5 and SNP #7 have a low correlation (0.32) with each other. Thus, you cannot reliably take SNP #5 and say that it could possibly act as a proxy for SNP #7.

LD Maps also tell us about HAPLOTYPE blocks. See the blocks labeled, "Block 1 (49kb)", "Block 2 (23kb)", "Block 3 (93kb)" ... and so on.


These triangles or the blocks of dark red represent SNPs that are all in high linkage disequilibrium with each other and thus are all inherited together. They are also on the same section of the chromosome. These SNPs form a HAPLOTYPE. Every big red triangle or block in the LD map indicates a HAPLOTYPE on the corresponding stretch of the chromosome above. You only need to look at one or maximum a couple SNPs in a haplotype to know about the fate of the entire section of the chromosome that forms a Haplotype. It saves money and time.

The HapMap Consortium project has painstakingly constructed such an LD map for each and every known SNP in the entire human genome. Their LD maps look somewhat like this (using the haploview software: )



Though it is complicated, if you followed the simple tutorial above, you should be able to make sense of even complicated maps such as these. You are most welcome to leave a comment or drop me an email if you need further clarification!

I don't care who is laughing at this ridiculously detailed explanation of a kindergarten concept in genetics and genomics. Personally, I am just EXTREMELY relieved to finally know it well enough to be able to explain it. :)

My current inspirational summer hero is (e:boxerboi). He is taking on the formidable MUSSELMAN TRIATHLON CHALLENGE!!! this weekend!



You could walk by his office and not notice the absolutely cool bloke who works there. But beneath his calm and almost zen-like efficiency lies the makings of a genuine hero! While lesser souls on the third floor show varying degrees of wimpiness and run around in circles, (e:boxerboi) quietly comes by and conquers the world! Like a true hero, he has a magically unceasing and very much hidden stash of some very lethal weapons.

1. Chuckles


2. Blueberries


Don't underestimate the power of these weapons of choice. They are jam-packed with massive undercurrents of overwhelming charm. Needless to say, I have been totally swept away and I hereby appoint him the

Hero of the Extreme 3rd Realm of Planet K


Join me in wishing him all the very best of luck in his mission to conquer the Musselman World not once, not twice but a WHOLE THREE TIMES!!

THREE CHEERS to you, (e:boxerboi)!!! You ROCK!!!