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Tinypliny's Journal

tinypliny
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07/14/2008 21:36 #45018

Tell me something true...
Category: art

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tinypliny - 07/18/08 21:11
I <3 Chillies! I know, the tomato isn't exactly shaped like the traditional heart but it comes much closer to the real one. ;)
boxerboi - 07/17/08 21:46
what's it mean?

07/13/2008 22:24 #45011

The Taste of Summer
Category: eating in
I made some absolutely delicious lunch today because I didn't want to go overboard eating all the junk food at the Taste of Buffalo. It's the same principle as eating something before going grocery shopping. I seldom follow that principle, however. I find that I am more alert if I don't eat before going to the grocery and make better and faster food decisions.

I am calling this the Taste of Summer. It has two of my very favourite ingredients. No, wait. Make that three.
1. Mustard Greens
2. Garlic
3. Bulghur Wheat
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It's an extremely quick recipe. Some of you might know how averse I am to using cooking oils other than my darling peanut oil but I made an exception and went with extra virgin olive oil today. The result blew me away. I am not a convert yet, but some of my insularity about cooking oils is slowly fading. Mind you, I still hate corn oil, canola, vegetable oil and the ilk. I especially loathe vegetable oil because I think it has a fishy unacceptable overtone. I am marginally okay with sesame oil if the dish calls for it. I am not saying that I would use oilive oil for regular cooking but I *might* consider it for light and offbeat cooking. Peanut oil still rules my cooking oil domain. If I had the misfortune to be stranded in an unknown nasty island, I would hunt for and take a bottle of Peanut oil with me when I am getting away from the wreck of the airplane. (Notice here, that I don't say "swimming away from the wreck of the boat". The reason being, I don't know how to swim.)

Here's how you concoct and distill the Taste of Summer.

1. Chop into very fine pieces
- Ginger
- Red Chillies
- Green Chillies (SUPER HOT!)
- Garlic
- Mustard Greens.
The key here is "very fine". You could make an exception for the Mustard Greens and go with just "coarse-fine".

2. Take Extra Virgin Olive oil in a sauteing pan
- Add a pinch of ground black pepper
- Add a pinch of semi-ground cumin
You have to have some full pieces of cumin here and some amount of cumin powder. It's a flavour balancing trick.

3. When the cumin begins to pop a bit
- Add the ginger, red chillies and garlic
Saute till the aroma of garlic wafts up and fills your kitchen. You may not want to wait that long if you live in the Buckingham Palace and your kitchen is the size of a warehouse.

4. Add Mustard greens and saute till the water comes out and the greens turn a very bright green.
This bright green can be precisely described as the green of the grass when the sun shines through and you wonder how it might be like to walk on it without any shoes on.

5. Add cooked Bulghur wheat (I would say in a 3 greens:1 wheat ratio) Don't add too much. The mustard greens, though very pungent, cannot beat the sheer carbohydraty-heaviness of Bulghur, so you might need a little moderation here. Favour the mustard greens, not the Bulghur.

6. Add cooked orange lentils (Around 3 tablespoons - not too much).
Same rule as above. Too much ruins the taste of mustard greens. And yes, I am not one of those people who primly list all the ingredients up front. I am assuming that you didn't start cooking the minute you started reading this journal and then found, when you hit step 6, that you didn't have any orange lentils to begin with. Deal with it.

7. Stir well. Turn off heat. If you don't, a kitchen fire will follow. Though it might well be in the spirit of summer with the heat and all, it won't quite match "The Taste of Summer". You get the idea.

8. To elevate the summer theme, garnish with a handful of HOT GREEN CHILLIES.

9. Enjoy with Lemonade. (You know the recipe for this, don't you?) What are you doing reading this recipe if you don't know how to squeeze a lemon into some cold water and add some honey, rock-salt and black pepper flakes to it?

10. Wish fervently that this summer goes by very very very slowly and winter forgets to visit Buffalo this year.

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07/12/2008 21:58 #44986

Congratulations, E:boxerboi!!!!!!!!!!!
Category: e:strip
What's an absolutely spellbinding story without a montage!??
Ready?? Cue the music >>>

::DOWNLOAD SOUND::



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I just received an awesome mail in my inbox!
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(E:boxerboi) successfully completed the Musselman Triathlon Challenge in 1:38:29!
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The Triathlon Challenge started early in the day...

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It was no walk in the park!!

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Or even a casual dance by the disco!

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It was a genuine time-bound sweat-drenched exhausting amphibious race!!

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A arduous triple trek through the tunnel of exertion and grit!

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But (e:boxerboi) completed it with flying colours!!
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image (E:boxerboi)!!!!!!
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imageYOU ARE MY HERO!image
boxerboi - 07/15/08 08:30
thanks everyone! It was so much fun. I can't wait to do the next one.
leetee - 07/12/08 22:17
wow. incredible. finishing at all is amazing... good time. thanks for letting us know, tiny! congrats boxerboi!
paul - 07/12/08 22:13
You are totally awesome (e:boxerboi) and tiny for your homage to him.

07/11/2008 18:20 #44934

Johnny Depp is Paul C. Kozlowski
Category: the odes
Or so I think.

Since I have a deadline, quite naturally, I have been afflicted by the ODES ((e:tinypliny,38711)) and I am off gallivanting to distant realms of the www. I chanced upon Chow Chocolat's myspace page. It lists the store as a 25 year old female in Buffalo, NY. I wonder if that is the demographic of clientele they hope to attract or just how young they feel... Anyway, their page has an intriguing little song called "Berlin" by a band called "Casperous Vine". It also has a to the band.

I couldn't help following it and the revelation of the evening is that its Johnny Depp's band! According to the page, Johnny Depp a.k.a Paul Christopher Kozlowski plays the Bayan, the Accordion, several types of Guitar (including Classical, Electric, Nylon), the oud, the fretless bass, vibraphone, jew harp, jaymar, porpoise, the trither, anu, marimba, glocks, vox, didj, scrap metal, keyboard/synthesizer, mandolin, percussion, flute, cello, violin and also an exotic and colourful looking self-assembled instrument called the Gilgamesh! Casperous Vine has released a CD compilation that is reviewed here. Their music is described as avante garde progressive electro-acoustic world-fusion! Kozlowski also plays in another rather interesting band called the Terrible Elephant. Give a listen to the song called "roompa" on this and you'll know what I mean.

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Is there a limit to this man's seemingly endless and fascinating qualities?!

- Passionate Cook
- Founder of an innovative band (and probably plays in two more).
- Composer of exotic music
- Can build musical instruments from Scratch.
- Plays several musical instruments
- Works at Chow Chocolat
- Looks heartbreakingly like Johnny Depp!
- Has a very charming smile and is extremely down-to-earth.
- Shook hands with Hillary Clinton

While I was google-stalking this captivating personality, I found (e:Jim)'s Flickr stream! Yep. Just like that Bacon bloke is six degrees away from everyone on the planet, I am convinced that (e:Jim) is just a google-stalk away from everyone! (e:Jim) and (e:James) are virtual friends with another Flickr photo-enthusiast called Planet Tyler whose Summer '07 muse was none other than Johnny Depp Kozlowski!


Buffalo is an incredibly personal city. :)

_________
PS: Readers having trouble placing this post in context should refer to this post about Chow Chocolat: (e:tinypliny,44289)
tinypliny - 07/11/08 18:51
Gee. So this Depp Doppelgänger's last name was Ulrich and he was possibly related to some Ulrich in Buffy who resembled that Ulrich from Metallica. Something tells me you would be excellent at the Bacon association game. Hahaha...

Chow Chocolat apparently has a stall at the Farmer's Market at Bidwell. So maybe they might be at the Taste as well. Who knows. Their chocolate (both drinking and eating) is nothing short of amazing! :)
metalpeter - 07/11/08 18:31
Yeah Johnny Depp is a pretty Handsome dude, I guess that guy kinda looks like the Younger Depp. But that brings up a question when Depp started acting there was a guy who looked a lot like him and I thought was about as good named Sket Ulrich (not sure if he is related to the Ulirch from Buffy who looked just like lars ulrich of metallica I'm not sure if the two actors names are spelled the same or not but Lars and the Professor or who ever he was from Metallica do spell there names the same) well what ever happened to him? I wonder if Chow Chocolat will be part of the taste of Buffalo? Well maybe you will find out before me, and maybe I'll see you there and maybe if I do I'll yell your name and then just to mess around offer you some thing with meat in it or some of what ever cold beverage I'm drinking. There are so many people that often I never see anyone I know. Later I will check out that place's my space page, Happy Friday!!!!!!

07/10/2008 17:51 #44920

Linkage Disequilibrium Blocks/Triangles
Category: science
I just had a zen moment in the interpretation of Linkage Disequilibrium Maps. (Also called LD maps, LD blocks, LD triangles - take your pick.) Turns out I was actually sweating 1st grade stuff!

I found that NO ONE explains this EXTRAORDINARILY SIMPLE thing in their umpteen papers, reviews, tutorials and what-nots. I just want to post this here so that when people google this simple little question, they find an equally simple and straight-forward answer!

This is an example of what a very small section of a Linkage Disequilibrium Map or an LD Map looks like.
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Concentrate on the upper part of the map.
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The thick blue line represents a strand of a chromosome. The white bars on the blue line of the chromosome are SNPs (Single Nucleotide Polymorphisms) that have been identified and sequenced. This means that we know what initial Nucleotide base has morphed into what final Nucleotide base. (Thus making it a polymorphic locus - or a position on the chromosome that exists in more than one form. The two forms are the intial nucleotide base and the final nucleotide base.)

These SNP locations or loci are labeled in this picture as 1, 2, 3, ... and so on. Each of these SNPs has a name that starts with rsXXXXX where XXXXX is some numeric code. Each SNP is represented by a labeled grey triangle below the thick blue line (the chromosome).
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The purpose of an LD map is to tell us whether any two given SNPs are INHERITED TOGETHER in an offspring. In other words, we want to know if any two given SNPs are in Linkage Disequilibrium.

An example: Are say, SNP #5 and SNP #9 in linkage disequilibrium? You trace down the column leading from grey triangle #5 or SNP#5 (Name: rs2299433) going toward SNP #9 (rs2237717). Do the same for SNP #9 going toward SNP #5.
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The square in which the columns leading from SNP #5 and SNP #9 intersect is the one you should focus on. I have encircled it above. As you can see its a LIGHT RED and has a number, 75. Thus SNP#5 and SNP #9 have a correlation of 0.75 and are in fairly high linkage disequilibrium with each other.

In simple terms, if your square of focus is a deep red, then the two SNPs you are interested in have the highest correlation with each other and have a highest Linkage Disequilibrium. Thus, one of them can easily act as a proxy for another. The lighter the shade of red, the lesser is the correlation between the two SNPs. For example, SNP #5 and SNP #7 have a low correlation (0.32) with each other. Thus, you cannot reliably take SNP #5 and say that it could possibly act as a proxy for SNP #7.

LD Maps also tell us about HAPLOTYPE blocks. See the blocks labeled, "Block 1 (49kb)", "Block 2 (23kb)", "Block 3 (93kb)" ... and so on.
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These triangles or the blocks of dark red represent SNPs that are all in high linkage disequilibrium with each other and thus are all inherited together. They are also on the same section of the chromosome. These SNPs form a HAPLOTYPE. Every big red triangle or block in the LD map indicates a HAPLOTYPE on the corresponding stretch of the chromosome above. You only need to look at one or maximum a couple SNPs in a haplotype to know about the fate of the entire section of the chromosome that forms a Haplotype. It saves money and time.

The HapMap Consortium project has painstakingly constructed such an LD map for each and every known SNP in the entire human genome. Their LD maps look somewhat like this (using the haploview software: )

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Though it is complicated, if you followed the simple tutorial above, you should be able to make sense of even complicated maps such as these. You are most welcome to leave a comment or drop me an email if you need further clarification!

I don't care who is laughing at this ridiculously detailed explanation of a kindergarten concept in genetics and genomics. Personally, I am just EXTREMELY relieved to finally know it well enough to be able to explain it. :)
YesThatCasey - 03/26/14 00:18
What a cool little slice to pop up. I need to read this later
raddna - 03/26/14 00:10
Awesome explanation. Totally simplified.
tinypliny - 07/10/08 21:47
Wow!! You should totally apply! You'd make an awesome Epidemiologist!! Let me know if I can propel your thoughts a bit more toward Epi. I think (e:boxerboi) is seriously considering Epi as well. The future is in Genetic/Molecular Epi and population studies.
terry - 07/10/08 21:21
More and more I think this may be where I am heading... From chemistry to biology to biochemistry to microbiology to genetic epidemiology...seems logical to me.

Can't wait to join you.
tinypliny - 07/10/08 20:48
That's funny, (e:heidi). :)
Thanks for commenting! Just to make it a bit more clear, I think I should add a simplified explanation of why exactly its called Linkage Disequilibrium when two SNPs are inherited together. The first part is easy. The SNPs are linked together on the same chromosome-> hence "Linkage". It's a disequilibrium because if they had not been linked together (or had been independent of each other), the offspring would be as likely to not inherit the two SNPs together as they would be to inherit them together. So there would be a 50/50 chance of getting them together or not getting them together, from the parents. Thus, if you examined a huge number of offspring and looked to see whether they have any two independent/unlinked SNPs, you would find an equilibrium between the condition of inheriting the two SNPs together and the condition of inheriting only one of the SNPs.

A more rigorous and mathematical explanation of the above is called the Hardy-Weinberg Equilibrium/Principle/Law in Genetics. :::link:::
heidi - 07/10/08 19:27
Wow, Tiny! That's really cool. Not that I'd ever heard of linkage disequilibrium before just now... but learning the word "disequilibrium" alone was worth reading this. :-)